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There'd be a brief withdrawal period where everyone is fucked up from not having their antidepressants, anxiolytics, and caffeine, but things would get back to normal in a week or two. If you're talking recreational drugs, no; we're in a minority.
I was thinking that drugs were kind of a support of this country in a way. Alot of money to being made. Plus all the jobs of people that bust people for drugs. Less money comming into the government from tickets and shit. idk just a thought