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OfflineShaggy420
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Magic mushroom’s positive effects lasting over a year, say researchers * 1
    #565011 - 06/17/11 06:22 AM (5 years, 5 months ago)

Scientists at the Johns Hopkins University School of Medicine claim to have determined the proper dose levels needed to create positive changes in attitudes, mood, life satisfaction, and behavior that persist for more than a year with the psychoactive substance in so-called "magic mushrooms."

The findings are the latest in a series of experiments done at Johns Hopkins to investigate psilocybin, a psychedelic substance contained in certain mushrooms. The findings were published online this week in the peer-reviewed journal Psychopharmacology.

“In cultures before ours, the spiritual guide or healer had to discern how much of what type of mushroom to use for what purposes, because the strength of psychoactive mushrooms varies from species to species and even from specimen to specimen," said Roland Griffiths, Ph.D., a professor of psychiatry and behavioral sciences and neuroscience at the Johns Hopkins University School of Medicine and the study's lead scientist.

"In our laboratory, weʼre working with the pure chemical psilocybin, which we can measure out precisely," he added. "We wanted to take a methodical look at how its effects change with dosage. We seem to have found levels of the substance and particular conditions for its use that give a high probability of a profound and beneficial experience, a low enough probability of psychological struggle, and very little risk of any actual harm."

SIMILAR: First therapeutic study of LSD in 35 years finishes treatment of last subject

The researchers said 94 percent of the study's 18 participants rated their experiences with psilocybin as among the top five most or as the top most spiritually significant experience of his or her life at a 14-month follow-up. Eighty-four percent also reported positive changes in their behaviors, changes like improved relationships with family and others, increased physical and psychological self-care, and increased devotion to spiritual practice, which were corroborated by family members and others.

"I feel that I relate better in my marriage," one participant reported. "There is more empathy – a greater understanding of people and understanding their difficulties and less judgment."

The participants, ages 29 to 62, were screened to include only those who were deemed psychologically and physically healthy. Each participant received five closely-monitored, eight-hour psilocybin sessions a month apart. Each session had a different dose of psilocybin, with one session using a placebo, and was "blind," meaning neither the participants, the monitors, nor the scientists knew how much psilocybin - if any - had been given during any session.

At higher doses of psilocybin, nearly a third of the participants experienced great fear or had delusions, but with gentle guidance from researchers, those reactions did not outlast the psilocybin session or harm the participants. Those who received lower doses of the psychedelic before the higher doses were the most likely to have long-lasting positive changes in attitudes and behavior.

Potential psychotherapeutic value of 'magic mushrooms'

"The Hopkins psilocybin studies clearly demonstrate that this route to the mystical is not to be walked alone," Jerome Jaffe, M.D., who served as the first White House "Drug Czar," commented. "But they have also demonstrated significant and lasting benefits."

"That raises two questions: Could psilocybin-occasioned experiences prove therapeutically useful, for example in dealing with the psychological distress experienced by some terminal patients? And should properly-informed citizens, not in distress, be allowed to receive psilocybin for its possible spiritual benefits, as we now allow them to pursue other possibly risky activities such as cosmetic surgery and mountain-climbing?"

A similar study published in the Archives of General Psychiatry in January found psilocybin can safely improve the moods of patients with advanced-stage cancer and anxiety.

The study was headed by Dr. Charles S. Grob, a professor of psychiatry at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center and found a significant improvement of mood and a reduction in symptoms of anxiety up to six months after receiving psilocybin-assisted therapy.

"We are working with a patient population that often does not respond well to conventional treatments," said Grob. "Following their treatments with psilocybin, the patients and their families reported benefit from the use of this hallucinogen in reducing their anxiety. This study shows psilocybin can be administered safely, and that further investigation of hallucinogens should be pursued to determine their potential benefits."

Although some may be concerned that a relatively unstudied and illegal substance such as psilocybin could pose health risks, a study published in the Psychopharmacology in 2004 found there is "no cause for concern that [psilocybin] is hazardous with respect to somatic health" in healthy adults.

The only physiological side-effects the study found was a brief increase in blood pressure and a small increase in levels of thyroid-stimulating-hormone (TSH), prolactin, cortisol, and adrenocorticotropic hormone. None of these side-effects were considered dangerous to healthy adults.

"Typically, the experiences after [medium and high doses of psilocybin] were rated positive, with retrospective statements ranging from ‘pleasurable’ to ‘ineffably beautiful,’ " according to the study. One volunteer had a fearful experience after being given a high dose of psilocybin, but his anxiety was resolved without the need for pharmacological intervention.

"We know that psilocybin is remarkably non-toxic to the bodyʼs organ systems," Matthew Johnson, Ph.D., an assistant professor of psychiatry and behavioral sciences at Johns Hopkins and lead author of an earlier Hopkins paper on hallucinogen safety remarked. "But there are indirect risks: if someone experiences high anxiety, fear, or paranoia during a psilocybin session, itʼs not hard to imagine them behaving in ways harmful to themselves or others."

"These risks appear to be minimized when volunteers develop a trusting relationship with a skilled monitor, who remains present with them for the duration of the substanceʼs primary effects, and who is available afterwards for consultation."


http://www.rawstory.com/rs/2011/06/15/magic-mushrooms-positive-clinical-effects-lasting-over-a-year-say-researchers/


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Offlineblurt
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Registered: 01/18/11
Posts: 36
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: Shaggy420]
    #565040 - 06/17/11 10:11 AM (5 years, 5 months ago)

''At higher doses of psilocybin, nearly a third of the participants experienced great fear or had delusions.'' Well what did you think would happen lol, besides ive never been scared no matter the amount and delusions? No I hallucinate, only ever been delusional from sleep deprivation.

But it is nice to see that the drugs under prohibition are actually prooving usefull. Suck on that government.


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Invisiblemhbound
Ballin out at all cost
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Registered: 09/22/08
Posts: 8,142
Loc: High Flag
Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: blurt] * 1
    #565070 - 06/17/11 01:09 PM (5 years, 5 months ago)

I trip acid about once a year sometimes more if I'm at shows or whatever but really only once at a high dose to get a full on experience. And I swear to god like no joke I have no desire to do it for 6 months or more....I literally feel renewed and just an overall sense of wellbeing.

I don't understand how the government can take that away from people, it could literally change lives...I've never told anyone this before but I ate 8 hits and had a bad trip and I was going to kill myself because I had been in a bad rut for several years and I loaded the gun and broke down and where I couldn't experience feelings like literally I don't get really happy or anything so I just felt like not living, but the LSD put me in my place.

Life has a whole new meaning to me now. Same with shrooms I do them a few times a year just to keep me centered.

Its pathetic they are doing this shit. The USA was founded on the bible teaching yadadadadyadada, okay if thats true it clearly says about the whole every herb and seed bearing whatever is meant for us...................How can you be so hypocritical. Those people are fucking idiots.

LSD, shrooms, mescaline, etc I honestly believe could keep people from killing themselves. For those people who are numb like myself the only time you feel the emotions are tripping, it gives you a reason to keep going if you are struggling it shows you that things can get better.

The government is about full of some of the most irrational people I have ever seen in my life.


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Suck my balls America


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Offlinesmurf_master
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Registered: 05/12/11
Posts: 413
Loc: Everywhere Flag
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: mhbound]
    #565082 - 06/17/11 02:45 PM (5 years, 5 months ago)

So doing mushrooms once every sunday is a good thing?


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Invisiblemhbound
Ballin out at all cost
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Registered: 09/22/08
Posts: 8,142
Loc: High
Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: smurf_master]
    #565110 - 06/17/11 03:46 PM (5 years, 5 months ago)

i think so. i do it about once a month but ive done it a lot so i try to slow down


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Offlineblurt
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Registered: 01/18/11
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: mhbound] * 1
    #565269 - 06/18/11 01:06 AM (5 years, 5 months ago)

They helped with my depression, which turned out was caused by undiagnosed ADHD and loosing my my ming really, but shrooms help me along helped me to see things for what they are and now im comletely centred and dont even drink alcahol anymore and ive been a heavy user since 13/14.


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Invisiblemhbound
Ballin out at all cost
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Registered: 09/22/08
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: blurt]
    #565277 - 06/18/11 01:21 AM (5 years, 5 months ago)

I feel like ADHD is misdiagnosed as  another illness.....OCD mainly. Thats me though.


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Offlineboodle
Get to the chopper!
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Registered: 06/17/11
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Last seen: 4 years, 8 months
Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: mhbound]
    #565313 - 06/18/11 02:40 AM (5 years, 5 months ago)

Quote:

mhbound said:
I feel like ADHD is misdiagnosed as  another illness.....OCD mainly. Thats me though.



Im curious, why do you say this?


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Offlinesmurf_master
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Registered: 05/12/11
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: boodle]
    #565317 - 06/18/11 03:09 AM (5 years, 5 months ago)

ADHD is fake.


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Offlineblurt
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Registered: 01/18/11
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: smurf_master]
    #565551 - 06/19/11 04:22 AM (5 years, 5 months ago)

Quote:

smurf_master said:
ADHD is fake.





It's taken me a while to figure it out, sent me loopy figuring out if it real or not. At the end of the day you cant say its fake, because then that means you think alzheimer's and autism is fake as they have low seritonin levels resulting in loss of control. Something like that anyway, when I have no drugs, alcahol, caffeine, sugar in my system for an extended time over months, eating 3 times a day high proteine and well a decent diet. Im a hyperactive impulsive mess, have a couple caffeine tabs and I stop and sit and can watch tv or read. At the end ofthe day it doesnt matter if its real or not the matter of it is, is that at the end of the day stims work so in a sence makes it real. But I can honestly say my impulses are not pre-thought out. My heart and brain do to different things. Im 25 so it not really civilised.


Edited by blurt (06/19/11 04:25 AM)


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Invisiblemhbound
Ballin out at all cost
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Registered: 09/22/08
Posts: 8,142
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: blurt]
    #565553 - 06/19/11 04:55 AM (5 years, 5 months ago)

A log of mental illness comes form learned behaviors not genetics IMO...But there are that do. Our brains are powerful I mean like if you were raped over and over as a child your mind could actually convince yourself that its not even happening etc.

High


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OfflineKrackatus
Vapehead


Registered: 06/29/10
Posts: 177
Loc: UK
Last seen: 1 year, 5 months
Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: mhbound]
    #565583 - 06/19/11 08:41 AM (5 years, 5 months ago)

If i'm still alive when the western governments of the world finally recognise that psychedelics have genuine theraputic value, i'll be sitting in an arm chair clapping very slowly.  :congrats:
Well done guys, how long has it taken you to realise this? The people of Amazonia and native america have known this for thousands of years. Yet most people in our society will look at those people as primitive simpletons who live in huts. Oh the irony..  :shake:


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"Cannabis is not a health problem. The problem is that it promotes social values and attitudes which are unwelcome in capitalist market based society. It's just that simple." - Terence McKenna


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Offlineblurt
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: mhbound]
    #565588 - 06/19/11 09:45 AM (5 years, 5 months ago)

Quote:

mhbound said:
A log of mental illness comes form learned behaviors not genetics IMO...But there are that do. Our brains are powerful I mean like if you were raped over and over as a child your mind could actually convince yourself that its not even happening etc.

High





Totally, but the thing was I never really struggled with my ADHD but I was a nightmare but was having fun doing it. But ya get to the point where everything around you falls apart and nobody likes you. The past 3yrs, I had convinced myself I had no emotions or cared (which is in a way a learned behaviour) because I did things all the time learned to not feel guild for what ever I did. Got assessed and got counciling and started using 'shrooms' again after not touching for 7yrs. I did a complete 180 and feeling and emotions have come back and now that I understand the ADHD I can stop, think, figure out what im doing (when talking) physical is harder. But im a better person. I owe a big part to the mushrooms because I saw things different.


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OfflineeNtranceAsexit
Bang-a-Bang-Boogie


Registered: 11/23/10
Posts: 1,345
Last seen: 8 days, 3 hours
Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: smurf_master]
    #568626 - 06/30/11 04:56 AM (5 years, 5 months ago)

Quote:

smurf_master said:
ADHD is fake.




and you are a doctor.


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Offlinesmurf_master
Master Smurf


Registered: 05/12/11
Posts: 413
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Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: eNtranceAsexit]
    #570359 - 07/07/11 01:36 PM (5 years, 5 months ago)

with a PHD in fake diseases like alcoholism and addiction.


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OfflineeNtranceAsexit
Bang-a-Bang-Boogie


Registered: 11/23/10
Posts: 1,345
Last seen: 8 days, 3 hours
Re: Magic mushroom’s positive effects lasting over a year, say researchers [Re: smurf_master]
    #570599 - 07/08/11 04:04 AM (5 years, 5 months ago)

ADD is misdiagnosed that is for sure... and it's not so much a disease... as a psychological problem.

that can controlled.





:hotidea:


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