Welcome to the Growery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!
|
 FRACTALife
Rust Fuckin' Cohle
 
Registered: 03/19/10
Posts: 6,838
Loc: Carcosa 
Last seen: 9 years, 1 month
|
 Psychopharmacology 
#413173 - 05/06/10 05:15 PM (15 years, 11 months ago) |
|
|
I really dig psychopharmacology it is very interesting.
I like learning about how drugs work in our brain and how they interact with our body.
What are some interesting psychopharmacology facts or cool things you have learned about such subjects.
I guess I like the mechanism of action part the most.
I'll start. 
Some NMDA receptor antagonists, including ketamine (K), dextromethorphan (DXM), phencyclidine (PCP), Ibogaine, and nitrous oxide (N2O) are popular as recreational drugs for their dissociative, hallucinogenic, and/or euphoriant properties. When used recreationally, they are classified as dissociative drugs. Because some users use them for spiritual reasons, these recreational NMDA receptor antagonists are sometimes considered to be entheogens.
Salvia, ketamine, and DMT all have some, not all, receptors in common.
Question for you guys.
I heard that serotonin and nonepiniephrin are responsible for the high of orgasm. But... isn't oxytocin also? Is serotonin relationship with orgasm the reason why SSRI's fuck, pun intended, with sex drive?
A few more...
The atropine class of drugs is named after a greek goddess of death  not really MOA but still 
people who use ayahuasca have more serotonin receptors than those who do not
xanax, alcohol, and other gabba drugs can cause anterograde amnesia.
The function of the sigma receptors is poorly understood[4] though an endogenous ligand, dimethyltryptamine, was found to interact with sigma-1.[5][6] Activation of sigma receptors by an agonist ligand may induce hallucinogenic effects and also may be responsible for the paradoxical convulsions sometimes seen in opiate overdose. Drugs known to be sigma agonists include cocaine, diacetylmorphine, PCP, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberine. However the exact role of sigma receptors is difficult to establish as many sigma agonists also bind to other targets such as the κ-opioid receptor and the NMDA receptor. In animal experiments, sigma antagonists such as rimcazole were able to block convulsions from cocaine overdose. Sigma antagonists are also under investigation for use as antipsychotic medications.
Tylenol, acetaminophen, ability to stop pain is because of an endogenous Cannabinoid.
Menthol also acts as a weak kappa Opioid (same as salvia) receptor agonist.
--------------------
Edited by FRACTALife (05/06/10 05:18 PM)
|
DungenessDank
Lord of the Flies
Registered: 05/05/08
Posts: 9,372
Loc: PNW
Last seen: 12 years, 11 months
|
 Re: Psychopharmacology [Re: FRACTALife]
#413197 - 05/06/10 06:05 PM (15 years, 11 months ago) |
|
|
I always thought an orgasm's euphoria was more of a dopamine thing.
|
FRACTALife
Rust Fuckin' Cohle
Registered: 03/19/10
Posts: 6,838
Loc: Carcosa
Last seen: 9 years, 1 month
|
|
DungenessDank said:
I always thought an orgasm's euphoria was more of a dopamine thing.
That too I believe.
--------------------
|
FRACTALife
Rust Fuckin' Cohle
Registered: 03/19/10
Posts: 6,838
Loc: Carcosa
Last seen: 9 years, 1 month
|
|
Can someone list all endogenous psychedelic chemicals?
Also, drugs that block their actions?
--------------------
|
Harlz
Registered: 02/05/09
Posts: 4,449
Loc: cloudz
Last seen: 2 years, 3 months
|
Re: Psychopharmacology [Re: FRACTALife]
#413258 - 05/06/10 08:21 PM (15 years, 11 months ago) |
|
|
DMT is actively transported across the brain blood barrier, a characteristic unique to DMT.
DMT and psilocin differ by only 1 oxygen molecule, dr rick strassman suggests it is the orally active form of DMT.
|
FRACTALife
Rust Fuckin' Cohle
Registered: 03/19/10
Posts: 6,838
Loc: Carcosa
Last seen: 9 years, 1 month
|
Re: Psychopharmacology [Re: Harlz]
#413259 - 05/06/10 08:22 PM (15 years, 11 months ago) |
|
|
Harlz said:
DMT is actively transported across the brain blood barrier, a characteristic unique to DMT.
DMT and psilocin differ by only 1 oxygen molecule, dr rick strassman suggests it is the orally active form of DMT.
Indeed.
--------------------
| |
|
|
|
|
Threaded
Previous
Index
Next
Edit 
Reply 
