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Offlinekreg

Registered: 09/15/21
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You know you're higher than you wanted to get when...
    #852812 - 11/29/21 11:40 AM (2 years, 3 months ago)

When I worry that other people will think I'm high, as if I'd usually care.


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InvisibleDataM
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Re: You know you're higher than you wanted to get when... [Re: kreg] * 1
    #852819 - 11/29/21 01:16 PM (2 years, 3 months ago)

When I start worrying about my internal organs that I can feel moving around...

Like that scene from that crazy movie Annihilation. :gethigh:


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“The Universe is under no obligation to make sense to you” -NDT

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Offlinekreg

Registered: 09/15/21
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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852823 - 11/29/21 01:31 PM (2 years, 3 months ago)

Yeah, or start thinking about cataclysmic bodily events like stroke or heart failure
as if you're impervious to it when clear headed hahaha

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OfflineFleabag Friend
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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852824 - 11/29/21 01:36 PM (2 years, 3 months ago)

Ah, to worry about being high.
One of my worst was when I went to go see music that my buddy was playing at some fucking coffee house when I was 16.
I drove there with a another friend of mine cause he had gas in his truck and I had weed.
It turned out to be way more potent and I got SO fucking stoned. We smoked until we showed up there. And when we walk in, there's my buddies fucking MOTHER there to see her son play with the rest of his family.
Now we're 16 and its illegal here in TX and a lot of people still freak the fuck out about it. We didn't know what to think about that.
I was comfortable, but I Was probably the most stressed out I've ever been. That goofy bitch kept lookin funny at me I SWEAR. I still remember the strange glances from his family under those neon signs drinking their fuckin craft beer.


--------------------
Bassui wrote the following letter to one of his disciples who was about to die:
"The essence of your mind is not born, so it will never die. It is not an existence, which is perishable. It is not an emptiness, which is a mere void. It has neither color nor form. It enjoys no pleasures and suffers no pains.
"I know you are very ill. Like a good Zen student, you are facing that sickness squarely. You may not know exactly who is suffering, but question yourself: What is the essence of this mind? Think only of this. You will need no more. Covet nothing. Your end which is endless is as a snowflake dissolving in the pure air."


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InvisibleConnectedcosmos
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Re: You know you're higher than you wanted to get when... [Re: Fleabag Friend] * 1
    #852829 - 11/29/21 02:06 PM (2 years, 3 months ago)

You put the milk in the cupboard and cereal in the fridge :spun:


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InvisibleDataM
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Re: You know you're higher than you wanted to get when... [Re: Connectedcosmos] * 1
    #852831 - 11/29/21 02:43 PM (2 years, 3 months ago)

Quote:

Connectedcosmos said:
You put the milk in the cupboard and cereal in the fridge :spun:




I did this silly shit stone-cold sober when I was in high school :dawerp:

My mom used to check behind me to make sure I didn't zombie-switch the cereal and milk in the morning.


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“The Universe is under no obligation to make sense to you” -NDT

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InvisibleConnectedcosmos
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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852836 - 11/29/21 04:15 PM (2 years, 3 months ago)

Quote:

Data said:
Quote:

Connectedcosmos said:
You put the milk in the cupboard and cereal in the fridge :spun:




I did this silly shit stone-cold sober when I was in high school :dawerp:

My mom used to check behind me to make sure I didn't zombie-switch the cereal and milk in the morning.




:awehigh:


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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: Connectedcosmos]
    #852848 - 11/29/21 06:04 PM (2 years, 3 months ago)

Thread does not apply to me, it is literally impossible for me to reach said state :awehigh:


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InvisibleConnectedcosmos
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow] * 1
    #852850 - 11/29/21 06:12 PM (2 years, 3 months ago)

:notsureif:


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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: Connectedcosmos]
    #852851 - 11/29/21 06:21 PM (2 years, 3 months ago)

I'm not kidding :ancientaliens:

Edit: I'm not proud of this. I'm actually kinda upset. I want to reach this fabled "couchlock: :notsureif: to YOU


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bruh....
Ban Lotto

Edited by spirit_shadow (11/29/21 06:22 PM)

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Offlinekreg

Registered: 09/15/21
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852852 - 11/29/21 06:43 PM (2 years, 3 months ago)

you just need to make some edibles using extract

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OfflineTexas Honey Badger
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Re: You know you're higher than you wanted to get when... [Re: kreg] * 1
    #852853 - 11/29/21 06:46 PM (2 years, 3 months ago)

Fuck thats what made me have to crawl to the bed:picard:


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I eat Cobras and Hair Pie

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Offlinekreg

Registered: 09/15/21
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Re: You know you're higher than you wanted to get when... [Re: Texas Honey Badger]
    #852854 - 11/29/21 07:03 PM (2 years, 3 months ago)

Yeah the potency curve of weight of product smoked vs eaten is wild. I've been messing with edibles for a good while now and I still can't gauge the right amount, it's so easy to go overboard. Which isn't really that bad, if you're doing deserts just cut whatever with other regular deserts. Eat half an infused cookie instead of a whole one or even crumble up a quarter cookie and mix into icecream. Done that before.

When I get too high from edibles I get really fucking stoned first, then panicky too stoned, then I nod out while standing up lol

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852855 - 11/29/21 07:04 PM (2 years, 3 months ago)

Know you're way too high when you're in the kitchen about to eat the ingredients for stuff.

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OfflineFleabag Friend
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852861 - 11/29/21 08:47 PM (2 years, 3 months ago)

I'm fuckin Jelly


--------------------
Bassui wrote the following letter to one of his disciples who was about to die:
"The essence of your mind is not born, so it will never die. It is not an existence, which is perishable. It is not an emptiness, which is a mere void. It has neither color nor form. It enjoys no pleasures and suffers no pains.
"I know you are very ill. Like a good Zen student, you are facing that sickness squarely. You may not know exactly who is suffering, but question yourself: What is the essence of this mind? Think only of this. You will need no more. Covet nothing. Your end which is endless is as a snowflake dissolving in the pure air."


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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852869 - 11/30/21 06:12 AM (2 years, 3 months ago)

Quote:

kreg said:
you just need to make some edibles using extract



I can't :'( I've tried to explain this to everyone: EDIBLES HAVE ZERO EFFECT ON ME. I swear to God I can eat every single edible in one go that is given to me and not feel anything. I hate my body :frown: I would 100% quit smoking if I could get high via edibles :frown:


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bruh....
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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852872 - 11/30/21 07:00 AM (2 years, 3 months ago)

im just always skeptical when people say that. like you should be able to take any dabbable extract that gdts you high, stuff it in a capsule or even drop it on a tiny piece of bread and pop it,
thing is the receptors are multiple places in your body, actually  hardly in your lungs. moreso in your intestines and your brain, although ROA makes a difference,  youre still just putting the stuff in your blood ultimately

which makes me wonder, i wonder whos tried boofing extract lol
a warm cart syringe right up the butt hahaha

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852876 - 11/30/21 07:27 AM (2 years, 3 months ago)

Be prepared to lose all of your money because I will bet all of your money and win :house:


Edit: and be pissed off about it cos at the end of the day I lose cos I can't get high by edibles :notsureif:


Editx2: look, I have literally taken enough top shelf dispo edibles to get like 5 to 10 people high and still didn't feel anything :ancientaliens:


--------------------
bruh....
Ban Lotto

Edited by spirit_shadow (11/30/21 07:30 AM)

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852878 - 11/30/21 07:30 AM (2 years, 3 months ago)

:shrug: maybe you should try one of the new thc isolates like thc-o or delta10

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852880 - 11/30/21 07:34 AM (2 years, 3 months ago)

Ok you buy it for me cos I'm not wasting any more money lol


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bruh....
Ban Lotto

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852881 - 11/30/21 07:36 AM (2 years, 3 months ago)

Between salvia and thc edibles I have wasted a few hundred $$$ over the years. No more I say :kingcrankey:


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bruh....
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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852882 - 11/30/21 07:39 AM (2 years, 3 months ago)

see thats part of it thats getting me too, paying for edibles, youve tried making them yourself right? i would never buy edibles, so many people just think decarbing is superstition and then they wonder why no one buys their shit

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852886 - 11/30/21 07:51 AM (2 years, 3 months ago)

Yes. I've tried making them myself with my own weed, with weed I've bought, I've tried friends home made shit. Nothing. Not shit.


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bruh....
Ban Lotto

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852887 - 11/30/21 07:52 AM (2 years, 3 months ago)

I ONLY get high if I smoke or vape it.  And even then I've never reached the "couchlock" I've always heard about. I just feel more relaxed than normal which feels nice.


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bruh....
Ban Lotto

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852888 - 11/30/21 07:54 AM (2 years, 3 months ago)

The only substance I've ever tried that has actually fucked me up is mushrooms. I'm hella sensitive to them.


--------------------
bruh....
Ban Lotto

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852893 - 11/30/21 08:04 AM (2 years, 3 months ago)

Hmmmm

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InvisibleDataM
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852901 - 11/30/21 09:42 AM (2 years, 3 months ago)

There are studies demonstrating variation in the structure and expression of different enzymes involved in cannabinoid metabolism in humans, which can effect how different THC metabolites build up in the body after ingestion and inhalation.

My guess is that spirit is one of those people who has a form of CYP2C9 that poorly or slowly metabolizes delta-9-THC into 11-hydroxy-THC, but has a normal structure/expression of enzymes that convert 11-hydroxy-THC into the final metabolites excreted, which would result in negligible amounts of free 11-hydroxy in the blood to bind to cannabinoid receptors.

Since almost all of the THC in edibles goes through first-pass metabolism, 11-hydroxy is the dominant psychoactive form of THC when consuming edibles. When smoking, some of the THC gets converted to 11-hydroxy, but some of it also passes through the blood-brain barrier unchanged and binds directly to cannabinoid receptors as delta-9. If my guess is correct, this would mean that spirit only experiences delta-9-thc effects, but does not experience 11-hydroxy-thc effects, which is why he's never been able to get "too high", doesn't get high from edibles but can still get high from smoking, and probably has a pretty high base tolerance to THC in general.


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“The Universe is under no obligation to make sense to you” -NDT

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852904 - 11/30/21 10:38 AM (2 years, 3 months ago)

But aren't those enzymes used for other things in the digestive process as well? Like weren't if someone completely devoid of those enzymes wouldn't they also have some known medical issues? I'd imagine something like not being able to eat kale or some weird specific foods something. No?

Like if you just told me somebody was missing some opioid receptors I would expect that person to be a little off

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852907 - 11/30/21 10:47 AM (2 years, 3 months ago)

Quote:

Data said:
There are studies demonstrating variation in the structure and expression of different enzymes involved in cannabinoid metabolism in humans, which can effect how different THC metabolites build up in the body after ingestion and inhalation.

My guess is that spirit is one of those people who has a form of CYP2C9 that poorly or slowly metabolizes delta-9-THC into 11-hydroxy-THC, but has a normal structure/expression of enzymes that convert 11-hydroxy-THC into the final metabolites excreted, which would result in negligible amounts of free 11-hydroxy in the blood to bind to cannabinoid receptors.

Since almost all of the THC in edibles goes through first-pass metabolism, 11-hydroxy is the dominant psychoactive form of THC when consuming edibles. When smoking, some of the THC gets converted to 11-hydroxy, but some of it also passes through the blood-brain barrier unchanged and binds directly to cannabinoid receptors as delta-9. If my guess is correct, this would mean that spirit only experiences delta-9-thc effects, but does not experience 11-hydroxy-thc effects, which is why he's never been able to get "too high", doesn't get high from edibles but can still get high from smoking, and probably has a pretty high base tolerance to THC in general.



Hey Mr science man can you make me something that would make me able to get too high? Do I need to eat a specific strain of grass or something before ingestion? :awehigh:


Edit: that may also explain why I don't really feel different kinds of highs. I just feel high or not high.(I can feel high but just not crazy high like everyone else, as I said just relaxes me a bit, it's comfy)

Edited by spirit_shadow (11/30/21 10:53 AM)

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InvisibleConnectedcosmos
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow] * 1
    #852918 - 11/30/21 12:33 PM (2 years, 3 months ago)

You think that your dying


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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852921 - 11/30/21 12:44 PM (2 years, 3 months ago)

Quote:

(I can feel high but just not crazy high like everyone else, as I said just relaxes me a bit, it's comfy)




spirit hows your tolerance? do you smoke daily?

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InvisibleDataM
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852922 - 11/30/21 12:51 PM (2 years, 3 months ago)

Quote:

kreg said:
But aren't those enzymes used for other things in the digestive process as well? Like weren't if someone completely devoid of those enzymes wouldn't they also have some known medical issues? I'd imagine something like not being able to eat kale or some weird specific foods something. No?





Not necessarily.

CYP2C9 is a member of the cytochrome P450 superclass of oxidative enzymes. They are used as a catch-all metabolic enzyme that acts on endogenous and xenobiotic compounds. They are also known for being polymorphic (and in the case of CYP2C9, highly polymorphic). Because of their broad range of substrates, a minor change in structure may just adversely affect activity on one substrate or one class of substrates, but not necessarily all substrates. So while spirit's CYP2C9 enzymes might be bad at working on specific cannabinoids, that doesn't necessarily mean it's not effectively doing its job on arachidonic acid.

And I also mentioned it could be another step in the metabolism that is affecting the buildup of different psychoactive compounds. For instance, if CYP2C9 is over-expressed or overactive, then the psychoactive delta-9 could be oxidized to the psychoactive 11-hydroxy and then immediately to the non-psychoactive THC-COOH. This could also occur if the enzyme has low or average efficacy with the first step, and high efficacy with the 2nd step. Either way, the end result is that only a burst of THC straight to the brain will result in a significant high, while slower, more metabolized ingestion will be completely removed before it has time to reach the brain and bind to the CB receptors. There are also multiple enzymes in the P450 class of enzymes that can do these steps, so it may be a more complex interaction with similar results.

That being said, some enzymatic genotypes do change how certain endogenous and xenobiotic compounds are metabolized, and those changes may result in differing responses to body conditions and external compounds. This can range from detectable differences in ratios between compounds and compound metabolites in the body, all the way up to certain people needing a fraction or multiples of the average effective dose of a medication in order to get the desired effects without risk of OD or undesirable side effects. This is most obvious in different responses to various drugs between races[link] or between adults and children, and is one of the motivations for pharmacogenomics and tailoring a specific person's medication and treatments based on their genetics.

Quote:

kreg said:
Like if you just told me somebody was missing some opioid receptors I would expect that person to be a little off



You would be correct, behavioral changes due to various opioid receptor gene knockout has been observed and documented in mice [link]. But most people do not have a random gene knockout mutation, most living humans have gene mutations that affect (but not block) enzyme expression and/or activity. This results in more nuanced physiological or behavioral changes [link].

And I think we've had this discussion too, where spirit was discussing his abnormal reaction to opiates, suggesting that he may also have some variation in the expression or function of one or more opioid receptor genes.

Enzyme and receptor gene variations are pretty common, because neurotransmitter regulation is a very dynamic and reactionary response in the body, as is the chances of ingesting (either knowingly via substance abuse or accidentally with changing external environment) different compounds that could wipe out a whole human population, necessitating high variability in xenobiotic metabolic enzyme expression and structure to increase the adaptability of a human population to a changing external environment.

Quote:

spirit_shadow said:
Hey Mr science man can you make me something that would make me able to get too high? Do I need to eat a specific strain of grass or something before ingestion? :awehigh:




So I've always heard that mango can intensify the effects of cannabis, but I think this is because myrcene is found in both the more volatile terpene fraction of cannabis and mangoes, so I don't know if this will help you.

Oddly enough, THC and CBD are both inhibitors of CYP2C9, but with unknown strength in vivo, and your ad-hoc in vivo testing suggests that it doesn't help :dumblol:.

Amentoflavone is a strong inhibitor of CYP2C9, which will almost certainly intensify the high of smoked or vaped THC, and may or may not affect the ability to get high on edibles. Herbal supplements that contain a decent amount of amentoflavone are Ginko biloba and St. John's Wort.

Grapefruit has traditionally been used to potentiate the high of opiates via inhibition of P450 enzymes (primarily CYP3A4) by the compound bergamottin in the pulp of the grapefruit. It is also found in bergamot orange peel extract, which is used in the characteristic flavor of Earl Grey tea. You may find that ingestion of grapefruit or earl grey may provide some potentiating effect on a THC high, but be aware that bergamottin's effects can last for 3-7 days, and can get you into some trouble if you are taking any other prescription medications, or taking large amounts of caffeine.

Quote:

spirit_shadow said:
that may also explain why I don't really feel different kinds of highs. I just feel high or not high.(I can feel high but just not crazy high like everyone else, as I said just relaxes me a bit, it's comfy)



I would expect this to be the case if the P450 class of enzymes have structural or expression variations. Do you also have different high duration compared to others?

I would suggest you be very careful and mention some of your variability in response to medication if your doctor ever prescribes you anything you haven't taken before. It can get you into potentially dangerous territory if they blind-dose you, and it may be that you metabolize certain things faster than others, but certain things may metabolize slower than others as well. From our discussion on your experience with opiates, I'd say you have several variations in your metabolic system.

Biology is neato :2cents:


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“The Universe is under no obligation to make sense to you” -NDT

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852925 - 11/30/21 01:22 PM (2 years, 3 months ago)

I forgot about mangoes, yeah spirit try a mango before smoking or whatever. I think it works I can just never get myself to monch down an entire mango they're so tough... idk maybe i'm getting them too ripe

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InvisibleDataM
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852927 - 11/30/21 01:44 PM (2 years, 3 months ago)

I know I've felt some threshold weirdness from drinking some triple-strength St. John's Wort before, I'd be interested in setting up a measured amount of ground cannabis in a bowl, over 2 separate days, first without the SJW and then with SJW on the 2nd day. Do a little qualitative comparison and potentially take a trip to the moon on day 2. :gethigh:


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“The Universe is under no obligation to make sense to you” -NDT

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852965 - 11/30/21 07:44 PM (2 years, 3 months ago)

Quote:

Data said:
Quote:

kreg said:
But aren't those enzymes used for other things in the digestive process as well? Like weren't if someone completely devoid of those enzymes wouldn't they also have some known medical issues? I'd imagine something like not being able to eat kale or some weird specific foods something. No?





Not necessarily.

CYP2C9 is a member of the cytochrome P450 superclass of oxidative enzymes. They are used as a catch-all metabolic enzyme that acts on endogenous and xenobiotic compounds. They are also known for being polymorphic (and in the case of CYP2C9, highly polymorphic). Because of their broad range of substrates, a minor change in structure may just adversely affect activity on one substrate or one class of substrates, but not necessarily all substrates. So while spirit's CYP2C9 enzymes might be bad at working on specific cannabinoids, that doesn't necessarily mean it's not effectively doing its job on arachidonic acid.

And I also mentioned it could be another step in the metabolism that is affecting the buildup of different psychoactive compounds. For instance, if CYP2C9 is over-expressed or overactive, then the psychoactive delta-9 could be oxidized to the psychoactive 11-hydroxy and then immediately to the non-psychoactive THC-COOH. This could also occur if the enzyme has low or average efficacy with the first step, and high efficacy with the 2nd step. Either way, the end result is that only a burst of THC straight to the brain will result in a significant high, while slower, more metabolized ingestion will be completely removed before it has time to reach the brain and bind to the CB receptors. There are also multiple enzymes in the P450 class of enzymes that can do these steps, so it may be a more complex interaction with similar results.

That being said, some enzymatic genotypes do change how certain endogenous and xenobiotic compounds are metabolized, and those changes may result in differing responses to body conditions and external compounds. This can range from detectable differences in ratios between compounds and compound metabolites in the body, all the way up to certain people needing a fraction or multiples of the average effective dose of a medication in order to get the desired effects without risk of OD or undesirable side effects. This is most obvious in different responses to various drugs between races[link] or between adults and children, and is one of the motivations for pharmacogenomics and tailoring a specific person's medication and treatments based on their genetics.

Quote:

kreg said:
Like if you just told me somebody was missing some opioid receptors I would expect that person to be a little off



You would be correct, behavioral changes due to various opioid receptor gene knockout has been observed and documented in mice [link]. But most people do not have a random gene knockout mutation, most living humans have gene mutations that affect (but not block) enzyme expression and/or activity. This results in more nuanced physiological or behavioral changes [link].

And I think we've had this discussion too, where spirit was discussing his abnormal reaction to opiates, suggesting that he may also have some variation in the expression or function of one or more opioid receptor genes.

Enzyme and receptor gene variations are pretty common, because neurotransmitter regulation is a very dynamic and reactionary response in the body, as is the chances of ingesting (either knowingly via substance abuse or accidentally with changing external environment) different compounds that could wipe out a whole human population, necessitating high variability in xenobiotic metabolic enzyme expression and structure to increase the adaptability of a human population to a changing external environment.

Quote:

spirit_shadow said:
Hey Mr science man can you make me something that would make me able to get too high? Do I need to eat a specific strain of grass or something before ingestion? :awehigh:




So I've always heard that mango can intensify the effects of cannabis, but I think this is because myrcene is found in both the more volatile terpene fraction of cannabis and mangoes, so I don't know if this will help you.

Oddly enough, THC and CBD are both inhibitors of CYP2C9, but with unknown strength in vivo, and your ad-hoc in vivo testing suggests that it doesn't help :dumblol:.

Amentoflavone is a strong inhibitor of CYP2C9, which will almost certainly intensify the high of smoked or vaped THC, and may or may not affect the ability to get high on edibles. Herbal supplements that contain a decent amount of amentoflavone are Ginko biloba and St. John's Wort.

Grapefruit has traditionally been used to potentiate the high of opiates via inhibition of P450 enzymes (primarily CYP3A4) by the compound bergamottin in the pulp of the grapefruit. It is also found in bergamot orange peel extract, which is used in the characteristic flavor of Earl Grey tea. You may find that ingestion of grapefruit or earl grey may provide some potentiating effect on a THC high, but be aware that bergamottin's effects can last for 3-7 days, and can get you into some trouble if you are taking any other prescription medications, or taking large amounts of caffeine.

Quote:

spirit_shadow said:
that may also explain why I don't really feel different kinds of highs. I just feel high or not high.(I can feel high but just not crazy high like everyone else, as I said just relaxes me a bit, it's comfy)



I would expect this to be the case if the P450 class of enzymes have structural or expression variations. Do you also have different high duration compared to others?

I would suggest you be very careful and mention some of your variability in response to medication if your doctor ever prescribes you anything you haven't taken before. It can get you into potentially dangerous territory if they blind-dose you, and it may be that you metabolize certain things faster than others, but certain things may metabolize slower than others as well. From our discussion on your experience with opiates, I'd say you have several variations in your metabolic system.

Biology is neato :2cents:



You are cute assuming I have a doctor :lol: I don't remember the last time I was sick and I have never broken a bone so :shrug:


--------------------
bruh....
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OfflineFleabag Friend
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #852967 - 12/01/21 01:36 AM (2 years, 3 months ago)

Goddamn, data is one smart motherfucker. All of that went entirely over my head.

Can I pay you for lessons?


--------------------
Bassui wrote the following letter to one of his disciples who was about to die:
"The essence of your mind is not born, so it will never die. It is not an existence, which is perishable. It is not an emptiness, which is a mere void. It has neither color nor form. It enjoys no pleasures and suffers no pains.
"I know you are very ill. Like a good Zen student, you are facing that sickness squarely. You may not know exactly who is suffering, but question yourself: What is the essence of this mind? Think only of this. You will need no more. Covet nothing. Your end which is endless is as a snowflake dissolving in the pure air."


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InvisibleDataM
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Re: You know you're higher than you wanted to get when... [Re: Fleabag Friend]
    #852971 - 12/01/21 03:04 AM (2 years, 3 months ago)

Quote:

Fleabag Friend said:
Goddamn, data is one smart motherfucker. All of that went entirely over my head.

Can I pay you for lessons?



I was on a grapefruit supplement when writing all of that up, just start dosing grapefruit and everything will start coming together. :highfive:


--------------------
“The Universe is under no obligation to make sense to you” -NDT

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852973 - 12/01/21 07:26 AM (2 years, 3 months ago)

Lol just don't do that with dissociatives ahaha

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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852980 - 12/01/21 11:07 AM (2 years, 3 months ago)

dosing grapefruit huh? whats that supposed to do, give me big cajones?

And why would it be a bad idea to do dissociatives with it?


--------------------
Bassui wrote the following letter to one of his disciples who was about to die:
"The essence of your mind is not born, so it will never die. It is not an existence, which is perishable. It is not an emptiness, which is a mere void. It has neither color nor form. It enjoys no pleasures and suffers no pains.
"I know you are very ill. Like a good Zen student, you are facing that sickness squarely. You may not know exactly who is suffering, but question yourself: What is the essence of this mind? Think only of this. You will need no more. Covet nothing. Your end which is endless is as a snowflake dissolving in the pure air."


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InvisibleDataM
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Re: You know you're higher than you wanted to get when... [Re: Fleabag Friend]
    #852982 - 12/01/21 11:09 AM (2 years, 3 months ago)

Quote:

Fleabag Friend said:
dosing grapefruit huh? whats that supposed to do, give me big cajones?

And why would it be a bad idea to do dissociatives with it?




You get so mad dooted that you doodoot deedoodoot into the outer reaches of the dooterverse.


--------------------
“The Universe is under no obligation to make sense to you” -NDT

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Re: You know you're higher than you wanted to get when... [Re: Data]
    #852983 - 12/01/21 11:13 AM (2 years, 3 months ago)

woah, thatd be like, crazy maaan. I've never been that dooted except for this one time when I took like a hundred bong rips back to back with my best friend whosse like a black guy broo


--------------------
Bassui wrote the following letter to one of his disciples who was about to die:
"The essence of your mind is not born, so it will never die. It is not an existence, which is perishable. It is not an emptiness, which is a mere void. It has neither color nor form. It enjoys no pleasures and suffers no pains.
"I know you are very ill. Like a good Zen student, you are facing that sickness squarely. You may not know exactly who is suffering, but question yourself: What is the essence of this mind? Think only of this. You will need no more. Covet nothing. Your end which is endless is as a snowflake dissolving in the pure air."


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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: Fleabag Friend]
    #852988 - 12/01/21 12:11 PM (2 years, 3 months ago)

As far as dissociatives data I am dissapointed! CYP450 !!!! ugh they manilla effctd it just like magnesium but if you smoke pcp be fucking careful with the grapefruit shit
https://drugs-forum.com/threads/potentiating-dxm-with-grapefruit-juice.81325/page-3

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: Fleabag Friend]
    #852989 - 12/01/21 12:13 PM (2 years, 3 months ago)

Quote:

Fleabag Friend said:
woah, thatd be like, crazy maaan. I've never been that dooted except for this one time when I took like a hundred bong rips back to back with my best friend whosse like a black guy broo



lol dude black people smoke blunts :O

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InvisibleConnectedcosmos
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #852993 - 12/01/21 01:10 PM (2 years, 3 months ago)

I just became one with doot:mindblown:


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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: Connectedcosmos]
    #852994 - 12/01/21 01:19 PM (2 years, 3 months ago)

You know you're higher than you wanted to get when you need to get up to do stuff but it feels better to just wait a moment

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #853017 - 12/02/21 05:43 AM (2 years, 3 months ago)

Can't say that I ever have....:aweshit:


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Ban Lotto

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Offlinespirit_shadow
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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #853142 - 12/03/21 05:00 PM (2 years, 3 months ago)

I just got home from work and noticed something. I may not get couchlocked but I can get to my highest state(comfy) fast if I take a bigger dab. I just took a massive one and about died coughing but instantly got to my max that would normally take me about 3 dabs(I take relatively small dabs on average)

I can feel high. I just don't feel crazy high like everyone else and my eyes don't get red.....it's bullshit I want to be a stoner :frown:


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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow]
    #853149 - 12/03/21 05:12 PM (2 years, 3 months ago)

interesting  i usually feel like multiple smaller dabs gets me higher because less coughing rather than choking and dying for 15 min off of one that i cant even hold in lol

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Offlinekreg

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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #853150 - 12/03/21 05:14 PM (2 years, 3 months ago)

spirit have you tried putting a little concentrate on a piece of bread or in a capsule and eating it? i know i know edibles never work for you, but maybe somehow that could? i had to stop doing that because i would over shoot it every time and fall asleep

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Re: You know you're higher than you wanted to get when... [Re: spirit_shadow] * 1
    #853162 - 12/03/21 06:57 PM (2 years, 3 months ago)

Describe your inhalation technique when it comes to joints and the like.

Back when I first started smoking, when I took a hit off a blunt or joint or pipe, I would take a relatively easy hit, and then just exhale. You're smoking, but its not REALLY smoking. The smokes just entering and exiting with the movement of your breath.

I soon discovered I could get exponentially higher If I would take an easy drag, and then remove the weed and inhale a bunch of air on top of it. Really force yourself to expand your lungs to their absolute max, feel your ribcage move with that smoke in there. You can almost feel that deep breath push that hot smoke down into your abdomen. You'll also see when you exhale it'll take a second before you begin to see smoke. tr

It might be in your technique. Give that a shot.


--------------------
Bassui wrote the following letter to one of his disciples who was about to die:
"The essence of your mind is not born, so it will never die. It is not an existence, which is perishable. It is not an emptiness, which is a mere void. It has neither color nor form. It enjoys no pleasures and suffers no pains.
"I know you are very ill. Like a good Zen student, you are facing that sickness squarely. You may not know exactly who is suffering, but question yourself: What is the essence of this mind? Think only of this. You will need no more. Covet nothing. Your end which is endless is as a snowflake dissolving in the pure air."


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Offlinespirit_shadow
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I'm a teapot


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Re: You know you're higher than you wanted to get when... [Re: kreg]
    #853175 - 12/04/21 02:20 AM (2 years, 3 months ago)

Quote:

kreg said:
spirit have you tried putting a little concentrate on a piece of bread or in a capsule and eating it? i know i know edibles never work for you, but maybe somehow that could? i had to stop doing that because i would over shoot it every time and fall asleep



Yep. No effect lol


--------------------
bruh....
Ban Lotto

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